Erythroid lineage chromatin accessibility maps facilitate identification and validation of NFIX as a fetal hemoglobin repressor

Human genetics has validated de-repression of fetal gamma globin (HBG) in adult erythroblasts as a powerful therapeutic paradigm in diseases involving defective adult beta globin (HBB)(1). To identify factors involved in the switch from HBG to HBB expression, we performed Assay for Transposase Acces...

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Detalles Bibliográficos
Autores principales: Chaand, Mudit, Fiore, Chris, Johnston, Brian, D’Ippolito, Anthony, Moon, Diane H., Carulli, John P., Shearstone, Jeffrey R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10267139/
https://www.ncbi.nlm.nih.gov/pubmed/37316562
http://dx.doi.org/10.1038/s42003-023-05025-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10267139/
https://www.ncbi.nlm.nih.gov/pubmed/37316562
http://dx.doi.org/10.1038/s42003-023-05025-4

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