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Erythroid lineage chromatin accessibility maps facilitate identification and validation of NFIX as a fetal hemoglobin repressor
Human genetics has validated de-repression of fetal gamma globin (HBG) in adult erythroblasts as a powerful therapeutic paradigm in diseases involving defective adult beta globin (HBB)(1). To identify factors involved in the switch from HBG to HBB expression, we performed Assay for Transposase Acces...
Autores principales: | Chaand, Mudit, Fiore, Chris, Johnston, Brian, D’Ippolito, Anthony, Moon, Diane H., Carulli, John P., Shearstone, Jeffrey R. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10267139/ https://www.ncbi.nlm.nih.gov/pubmed/37316562 http://dx.doi.org/10.1038/s42003-023-05025-4 |
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