Computational engineering of previously crystallized pyruvate formate-lyase activating enzyme reveals insights into SAM binding and reductive cleavage

Radical S-adenosyl-l-methionine (SAM) enzymes are ubiquitous in nature and carry out a broad variety of difficult chemical transformations initiated by hydrogen atom abstraction. Although numerous radical SAM (RS) enzymes have been structurally characterized, many prove recalcitrant to crystallizati...

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Detalles Bibliográficos
Autores principales: Moody, James D., Hill, Sarah, Lundahl, Maike N., Saxton, Aubrianna J., Galambas, Amanda, Broderick, William E., Lawrence, C. Martin, Broderick, Joan B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10267522/
https://www.ncbi.nlm.nih.gov/pubmed/37156396
http://dx.doi.org/10.1016/j.jbc.2023.104791

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