Angiopoietin-2–Dependent Spatial Vascular Destabilization Promotes T-cell Exclusion and Limits Immunotherapy in Melanoma

T-cell position in the tumor microenvironment determines the probability of target encounter and tumor killing. CD8(+) T-cell exclusion from the tumor parenchyma is associated with poor response to immunotherapy, and yet the biology that underpins this distinct pattern remains unclear. Here we show...

Descripción completa

Detalles Bibliográficos
Autores principales: Park, Ha-Ram, Shiva, Anahita, Cummings, Portia, Kim, Seoyeon, Kim, Sungsoo, Lee, Eunhyeong, Leong, Alessandra, Chowdhury, Subrata, Shawber, Carrie, Carvajal, Richard, Thurston, Gavin, An, Joon-Yong, Lund, Amanda W., Yang, Hee Won, Kim, Minah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2023
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10267677/
https://www.ncbi.nlm.nih.gov/pubmed/37093870
http://dx.doi.org/10.1158/0008-5472.CAN-22-2838

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10267677/
https://www.ncbi.nlm.nih.gov/pubmed/37093870
http://dx.doi.org/10.1158/0008-5472.CAN-22-2838

Ejemplares similares