Angiopoietin-2–Dependent Spatial Vascular Destabilization Promotes T-cell Exclusion and Limits Immunotherapy in Melanoma

T-cell position in the tumor microenvironment determines the probability of target encounter and tumor killing. CD8(+) T-cell exclusion from the tumor parenchyma is associated with poor response to immunotherapy, and yet the biology that underpins this distinct pattern remains unclear. Here we show...

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Detalles Bibliográficos
Autores principales: Park, Ha-Ram, Shiva, Anahita, Cummings, Portia, Kim, Seoyeon, Kim, Sungsoo, Lee, Eunhyeong, Leong, Alessandra, Chowdhury, Subrata, Shawber, Carrie, Carvajal, Richard, Thurston, Gavin, An, Joon-Yong, Lund, Amanda W., Yang, Hee Won, Kim, Minah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2023
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10267677/
https://www.ncbi.nlm.nih.gov/pubmed/37093870
http://dx.doi.org/10.1158/0008-5472.CAN-22-2838

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