Distinct Nrf2 Signaling Thresholds Mediate Lung Tumor Initiation and Progression

Mutations in the KEAP1–NRF2 (Kelch-like ECH-associated protein 1–nuclear factor-erythroid 2 p45-related factor 2) pathway occur in up to a third of non–small cell lung cancer (NSCLC) cases and often confer resistance to therapy and poor outcomes. Here, we developed murine alleles of the KEAP1 and NR...

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Detalles Bibliográficos
Autores principales: DeBlasi, Janine M., Falzone, Aimee, Caldwell, Samantha, Prieto-Farigua, Nicolas, Prigge, Justin R., Schmidt, Edward E., Chio, Iok In Christine, Karreth, Florian A., DeNicola, Gina M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2023
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10267679/
https://www.ncbi.nlm.nih.gov/pubmed/37062029
http://dx.doi.org/10.1158/0008-5472.CAN-22-3848

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10267679/
https://www.ncbi.nlm.nih.gov/pubmed/37062029
http://dx.doi.org/10.1158/0008-5472.CAN-22-3848

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