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Distinct Nrf2 Signaling Thresholds Mediate Lung Tumor Initiation and Progression
Mutations in the KEAP1–NRF2 (Kelch-like ECH-associated protein 1–nuclear factor-erythroid 2 p45-related factor 2) pathway occur in up to a third of non–small cell lung cancer (NSCLC) cases and often confer resistance to therapy and poor outcomes. Here, we developed murine alleles of the KEAP1 and NR...
Autores principales: | DeBlasi, Janine M., Falzone, Aimee, Caldwell, Samantha, Prieto-Farigua, Nicolas, Prigge, Justin R., Schmidt, Edward E., Chio, Iok In Christine, Karreth, Florian A., DeNicola, Gina M. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Association for Cancer Research
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10267679/ https://www.ncbi.nlm.nih.gov/pubmed/37062029 http://dx.doi.org/10.1158/0008-5472.CAN-22-3848 |
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