Structural and Functional Impact of Posttranslational Modification of Glypican-3 on Liver Carcinogenesis

Glypican-3 (GPC3) is a cell-surface glycoprotein that is frequently overexpressed in hepatocellular carcinoma (HCC). GPC3 undergoes extensive posttranslational modification (PTM) including cleavage and glycosylation. This review focuses on the structure and function of GPC3 in liver cancer, highligh...

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Detalles Bibliográficos
Autores principales: Schepers, Emily J., Glaser, Kathryn, Zwolshen, Harrison M., Hartman, Stephen J., Bondoc, Alexander J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10267680/
https://www.ncbi.nlm.nih.gov/pubmed/37027004
http://dx.doi.org/10.1158/0008-5472.CAN-22-3895

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10267680/
https://www.ncbi.nlm.nih.gov/pubmed/37027004
http://dx.doi.org/10.1158/0008-5472.CAN-22-3895

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