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Structural and Functional Impact of Posttranslational Modification of Glypican-3 on Liver Carcinogenesis
Glypican-3 (GPC3) is a cell-surface glycoprotein that is frequently overexpressed in hepatocellular carcinoma (HCC). GPC3 undergoes extensive posttranslational modification (PTM) including cleavage and glycosylation. This review focuses on the structure and function of GPC3 in liver cancer, highligh...
Autores principales: | Schepers, Emily J., Glaser, Kathryn, Zwolshen, Harrison M., Hartman, Stephen J., Bondoc, Alexander J. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Association for Cancer Research
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10267680/ https://www.ncbi.nlm.nih.gov/pubmed/37027004 http://dx.doi.org/10.1158/0008-5472.CAN-22-3895 |
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