Tracking and blocking interdependencies of cellular BRAF-MEK oncokinase activities

The selective targeting of mutated kinases in cancer therapies has the potential to improve therapeutic success and thereby the survival of patients. In the case of melanoma, the constitutively active MAPK pathway is targeted by a combinatorial inhibition of BRAF and MEK activities. These MAPK pathw...

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Detalles Bibliográficos
Autores principales: Fleischmann, Jakob, Schwaighofer, Selina, De Falco, Louis, Enzler, Florian, Feichtner, Andreas, Kugler, Valentina, Tschaikner, Philipp, Huber, Roland G, Stefan, Eduard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Biological, Health, and Medical Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10267685/
https://www.ncbi.nlm.nih.gov/pubmed/37325027
http://dx.doi.org/10.1093/pnasnexus/pgad185

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10267685/
https://www.ncbi.nlm.nih.gov/pubmed/37325027
http://dx.doi.org/10.1093/pnasnexus/pgad185

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