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Nicotinamide riboside functions during development while beta-hydroxybutyrate functions during adulthood to extend C. elegans lifespan

Nicotinamide riboside (NR), a form of vitamin B3 and a nicotinamide adenine dinucleotide (NAD (+) ) precursor, has been shown to activate the mitochondrial unfolded protein response (UPR (mt) ) and extend the lifespan when supplemented to C. elegans. The ketone body and histone deacetylase (HDAC) in...

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Detalles Bibliográficos
Autores principales: Peters, J. Dylan, Peters, McKenzie P., Bradshaw, Patrick C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Caltech Library 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10267727/
https://www.ncbi.nlm.nih.gov/pubmed/37325193
http://dx.doi.org/10.17912/micropub.biology.000841