Acute osimertinib exposure induces electrocardiac changes by synchronously inhibiting the currents of cardiac ion channels

Introduction: As the third generation of epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI), osimertinib has demonstrated more significant cardiotoxicity than previous generations of EGFR-TKIs. Investigating the mechanism of osimertinib cardiotoxicity can provide a reference for a...

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Detalles Bibliográficos
Autores principales: Li, Peiwen, Tian, Xiaohui, Wang, Gongxin, Jiang, Enshe, Li, Yanming, Hao, Guoliang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10267729/
https://www.ncbi.nlm.nih.gov/pubmed/37324483
http://dx.doi.org/10.3389/fphar.2023.1177003

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10267729/
https://www.ncbi.nlm.nih.gov/pubmed/37324483
http://dx.doi.org/10.3389/fphar.2023.1177003

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