Cargando…

Tonic activation of GABA(B) receptors via GAT-3 mediated GABA release reduces network activity in the developing somatosensory cortex in GAD67-GFP mice

The efficiency of neocortical information processing critically depends on the balance between the glutamatergic (excitatory, E) and GABAergic (inhibitory, I) synaptic transmission. A transient imbalance of the E/I-ratio during early development might lead to neuropsychiatric disorders later in life...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ueberbach, Timo, Simacek, Clara A., Tegeder, Irmgard, Kirischuk, Sergei, Mittmann, Thomas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10267986/ https://www.ncbi.nlm.nih.gov/pubmed/37325697 http://dx.doi.org/10.3389/fnsyn.2023.1198159

Ejemplares similares

Immunoreactivity for GABA, GAD65, GAD67 and Bestrophin-1 in the Meninges and the Choroid Plexus: Implications for Non-Neuronal Sources for GABA in the Developing Mouse Brain
por: Tochitani, Shiro, et al.
Publicado: (2013)

Localization and Function of GABA Transporters GAT-1 and GAT-3 in the Basal Ganglia
por: Jin, Xiao-Tao, et al.
Publicado: (2011)

Inhibition of Activity of GABA Transporter GAT1 by δ-Opioid Receptor
por: Pu, Lu, et al.
Publicado: (2012)

Compartmentalization of GABA Synthesis by GAD67 Differs between Pancreatic Beta Cells and Neurons
por: Kanaani, Jamil, et al.
Publicado: (2015)

GABA Release from Astrocytes in Health and Disease
por: Kilb, Werner, et al.
Publicado: (2022)

Evolutionary History of the GABA Transporter (GAT) Group Revealed by Marine Invertebrate GAT-1
por: Kinjo, Azusa, et al.
Publicado: (2013)

A Role for GAT-1 in Presynaptic GABA Homeostasis?
por: Conti, Fiorenzo, et al.
Publicado: (2011)

In Intact Islets Interstitial GABA Activates GABA(A) Receptors That Generate Tonic Currents in α-Cells
por: Jin, Yang, et al.
Publicado: (2013)

EXPLORING THE ROLE OF GAT1 AND GABA IN TEMOZOLOMIDE TREATED GLIOMA
por: Poole, Alisha, et al.
Publicado: (2023)

GABA(A) Receptor-Stabilizing Protein Ubqln1 Affects Hyperexcitability and Epileptogenesis after Traumatic Brain Injury and in a Model of In Vitro Epilepsy in Mice
por: Kürten, Tabea, et al.
Publicado: (2022)

Reduced tonic inhibition in striatal output neurons from Huntington mice due to loss of astrocytic GABA release through GAT-3
por: Wójtowicz, Anna M., et al.
Publicado: (2013)

Investigating the Role of GABA in Neural Development and Disease Using Mice Lacking GAD67 or VGAT Genes
por: Bolneo, Erika, et al.
Publicado: (2022)

Cognitive Impairment and the correlation with genetic Expression of GAD67, Gad65 and GABA beta2 Using Human Induced Pluripotent Stem Cells
por: Khalifa, D., et al.
Publicado: (2022)

GABA-activated Single-channel and Tonic Currents in Rat Brain Slices
por: Jin, Zhe, et al.
Publicado: (2011)

Activity-Dependent Modulation of Tonic GABA Currents by Endocannabinoids in Hirudo verbana
por: Paulsen, Riley T., et al.
Publicado: (2022)

Perinatal hypoxia: different effects of the inhibitors of GABA transporters GAT1 and GAT3 on the initial velocity of [(3)H]GABA uptake by cortical, hippocampal, and thalamic nerve terminals
por: Pozdnyakova, Natalia, et al.
Publicado: (2014)

Presynaptic GABA(B) receptor–mediated network excitation in the medial prefrontal cortex of Tsc2(+/-) mice
por: Bassetti, Davide, et al.
Publicado: (2021)

The effect of sodium thiopental as a GABA mimetic drug in neonatal period on expression of GAD65 and GAD67 genes in hippocampus of newborn and adult male rats
por: Naseri, Masoud, et al.
Publicado: (2017)

Toward dissecting the etiology of schizophrenia: HDAC1 and DAXX regulate GAD(67) expression in an in vitro hippocampal GABA neuron model
por: Subburaju, S, et al.
Publicado: (2016)

Impairment of GABA transporter GAT-1 terminates cortical recurrent network activity via enhanced phasic inhibition
por: Razik, Daniel S., et al.
Publicado: (2013)

Modeling and Simulation of hGAT1: A Mechanistic Investigation of the GABA Transport Process
por: Zafar, Sadia, et al.
Publicado: (2018)

Astrocytic proBDNF and Tonic GABA Distinguish Active versus Reactive Astrocytes in Hippocampus
por: Chun, Heejung, et al.
Publicado: (2018)

Insulin Regulates GABA(A) Receptor-Mediated Tonic Currents in the Prefrontal Cortex
por: Trujeque-Ramos, Saraí, et al.
Publicado: (2018)

Enhanced tonic GABA(A) inhibition in typical absence epilepsy
por: Cope, David W., et al.
Publicado: (2009)

Augmentation of Tonic GABA(A) Inhibition in Absence Epilepsy: Therapeutic Value of Inverse Agonists at Extrasynaptic GABA(A) Receptors
por: Errington, Adam C., et al.
Publicado: (2011)

Elevating Endogenous GABA Levels with GAT-1 Blockade Modulates Evoked but Not Induced Responses in Human Visual Cortex
por: Muthukumaraswamy, Suresh D, et al.
Publicado: (2013)

Gat1 (Gaba:Na(+):Cl(−)) Cotransport Function: Database Reconstruction with an Alternating Access Model
por: Hilgemann, Donald W., et al.
Publicado: (1999)

The transporter GAT1 plays an important role in GABA-mediated carbon-nitrogen interactions in Arabidopsis
por: Batushansky, Albert, et al.
Publicado: (2015)

Experimental and Bioinformatic Insights into the Effects of Epileptogenic Variants on the Function and Trafficking of the GABA Transporter GAT-1
por: Piniella, Dolores, et al.
Publicado: (2023)

A functional role for both γ-aminobutyric acid (GABA) transporter-1 and GABA transporter-3 in the modulation of extracellular GABA and GABAergic tonic conductances in the rat hippocampus
por: Kersanté, Flavie, et al.
Publicado: (2013)

Tonic excitation or inhibition is set by GABA(A) conductance in hippocampal interneurons
por: Song, Inseon, et al.
Publicado: (2011)

Extrasynaptic GABA(A) Receptors and Tonic Inhibition in Rat Auditory Thalamus
por: Richardson, Ben D., et al.
Publicado: (2011)

Methods for recording and measuring tonic GABA(A) receptor-mediated inhibition
por: Bright, Damian P., et al.
Publicado: (2013)

New GABA amides activating GABA(A)-receptors
por: Raster, Peter, et al.
Publicado: (2013)

Roles of taurine-mediated tonic GABA(A) receptor activation in the radial migration of neurons in the fetal mouse cerebral cortex
por: Furukawa, Tomonori, et al.
Publicado: (2014)

Functional Consequences of the Disturbances in the GABA-Mediated Inhibition Induced by Injuriesin the Cerebral Cortex
por: Imbrosci, Barbara, et al.
Publicado: (2011)

Opposite actions of alcohol on tonic GABA(A) receptor currents mediated by nNOS and PKC activity
por: Kaplan, Joshua S, et al.
Publicado: (2013)

Tonically Active α(5)GABA(A) Receptors Reduce Motoneuron Excitability and Decrease the Monosynaptic Reflex
por: Canto-Bustos, Martha, et al.
Publicado: (2017)

Tonic GABA(A) Receptors as Potential Target for the Treatment of Temporal Lobe Epilepsy
por: Schipper, S., et al.
Publicado: (2015)

Smoothened receptor signaling regulates the developmental shift of GABA polarity in rat somatosensory cortex
por: Delmotte, Quentin, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_2ua9gs2fi6n90gesneu6pn0588