Tumor cell–derived spermidine is an oncometabolite that suppresses TCR clustering for intratumoral CD8(+) T cell activation

The activation and expansion of T cells that recognize cancer cells is an essential aspect to antitumor immunity. Tumors may escape destruction by the immune system through ectopic expression of inhibitory immune ligands typically exemplified by the PD-L1/PD-1 pathway. Here, we reveal another facet...

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Detalles Bibliográficos
Autores principales: Hibino, Sana, Eto, Shotaro, Hangai, Sho, Endo, Keiko, Ashitani, Sanae, Sugaya, Maki, Osawa, Tsuyoshi, Soga, Tomoyoshi, Taniguchi, Tadatsugu, Yanai, Hideyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10268234/
https://www.ncbi.nlm.nih.gov/pubmed/37276392
http://dx.doi.org/10.1073/pnas.2305245120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10268234/
https://www.ncbi.nlm.nih.gov/pubmed/37276392
http://dx.doi.org/10.1073/pnas.2305245120

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