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Tumor cell–derived spermidine is an oncometabolite that suppresses TCR clustering for intratumoral CD8(+) T cell activation
The activation and expansion of T cells that recognize cancer cells is an essential aspect to antitumor immunity. Tumors may escape destruction by the immune system through ectopic expression of inhibitory immune ligands typically exemplified by the PD-L1/PD-1 pathway. Here, we reveal another facet...
| Autores principales: | , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
National Academy of Sciences
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10268234/ https://www.ncbi.nlm.nih.gov/pubmed/37276392 http://dx.doi.org/10.1073/pnas.2305245120 |