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The Drosophila chemokine–like Orion bridges phosphatidylserine and Draper in phagocytosis of neurons

Phagocytic clearance of degenerating neurons is triggered by “eat-me” signals exposed on the neuronal surface. The conserved neuronal eat-me signal phosphatidylserine (PS) and the engulfment receptor Draper (Drpr) mediate phagocytosis of degenerating neurons in Drosophila. However, how PS is recogni...

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Detalles Bibliográficos
Autores principales: Ji, Hui, Wang, Bei, Shen, Yifan, Labib, David, Lei, Joyce, Chen, Xinchen, Sapar, Maria, Boulanger, Ana, Dura, Jean-Maurice, Han, Chun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10268242/
https://www.ncbi.nlm.nih.gov/pubmed/37276397
http://dx.doi.org/10.1073/pnas.2303392120