Indole-carbohydrazide linked phenoxy-1,2,3-triazole-N-phenylacetamide derivatives as potent α-glucosidase inhibitors: design, synthesis, in vitro α-glucosidase inhibition, and computational studies

BACKGROUND: A new series of indole-carbohydrazide-phenoxy-1,2,3-triazole-N-phenylacetamide hybrids 11a–o was designed based on molecular hybridization of the active pharmacophores of the potent α-glucosidase inhibitors. These compounds were synthesized and evaluated against α-glucosidase. METHODS: T...

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Detalles Bibliográficos
Autores principales: Emadi, Mehdi, Mosavizadeh-Marvest, Fahimeh, Asadipour, Ali, Pourshojaei, Yaghoub, Hosseini, Samanesadat, Mojtabavi, Somayeh, Faramarzi, Mohammad Ali, Larijani, Bagher, Mohammadi-Khanaposhtani, Maryam, Mahdavi, Mohammad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10268488/
https://www.ncbi.nlm.nih.gov/pubmed/37316931
http://dx.doi.org/10.1186/s13065-023-00971-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10268488/
https://www.ncbi.nlm.nih.gov/pubmed/37316931
http://dx.doi.org/10.1186/s13065-023-00971-w

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