Real-time label-free detection of dynamic aptamer–small molecule interactions using a nanopore nucleic acid conformational sensor

Nucleic acids can undergo conformational changes upon binding small molecules. These conformational changes can be exploited to develop new therapeutic strategies through control of gene expression or triggering of cellular responses and can also be used to develop sensors for small molecules such a...

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Detalles Bibliográficos
Autores principales: Chingarande, Rugare G., Tian, Kai, Kuang, Yu, Sarangee, Aby, Hou, Chengrui, Ma, Emily, Ren, Jarett, Hawkins, Sam, Kim, Joshua, Adelstein, Ray, Chen, Sally, Gillis, Kevin D., Gu, Li-Qun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10268594/
https://www.ncbi.nlm.nih.gov/pubmed/37276386
http://dx.doi.org/10.1073/pnas.2108118120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10268594/
https://www.ncbi.nlm.nih.gov/pubmed/37276386
http://dx.doi.org/10.1073/pnas.2108118120

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