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Real-time label-free detection of dynamic aptamer–small molecule interactions using a nanopore nucleic acid conformational sensor
Nucleic acids can undergo conformational changes upon binding small molecules. These conformational changes can be exploited to develop new therapeutic strategies through control of gene expression or triggering of cellular responses and can also be used to develop sensors for small molecules such a...
| Autores principales: | , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
National Academy of Sciences
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10268594/ https://www.ncbi.nlm.nih.gov/pubmed/37276386 http://dx.doi.org/10.1073/pnas.2108118120 |