Cargando…

Dihydropyrazole Derivatives Act as Potent α-Amylase Inhibitors and Free Radical Scavengers: Synthesis, Bioactivity Evaluation, Structure–Activity Relationship, ADMET, and Molecular Docking Studies

[Image: see text] Dihydropyrazole (1–22) derivatives were synthesized from already synthesized chalcones. The structures of all of the synthesized compounds were confirmed by elemental analysis and various spectroscopic techniques. Furthermore, the synthesized compounds were screened against α amyla...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ali, Arif, Shah, Muhammad Ishaq Ali, Fu, Chaoping, Hussain, Zubair, Qureshi, Muhammad Nasimullah, Farman, Saira, Parveen, Zahida, Zada, Amir, Nayab, Saira, Fazil, Perveen, Ateeq, Muhammad, Rehman, Gauhar, Naeem, Mohammad, Ibrahim, Mohammad, Khan, Momin, Khan, Waliullah
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2023
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10268634/ https://www.ncbi.nlm.nih.gov/pubmed/37332823 http://dx.doi.org/10.1021/acsomega.3c00529

Ejemplares similares

Biosynthesis and Anti-inflammatory Activity of Zinc Oxide Nanoparticles Using Leaf Extract of Senecio chrysanthemoides
por: Zahoor, Sana, et al.
Publicado: (2023)

Evaluation of Alpha-Amylase Inhibitory, Antioxidant, and Antimicrobial Potential and Phytochemical Contents of Polygonum hydropiper L.
por: Nasir, Abdul, et al.
Publicado: (2020)

Thiophene-Derived Schiff Base Complexes: Synthesis, Characterization, Antimicrobial Properties, and Molecular Docking
por: Nayab, Saira, et al.
Publicado: (2023)

In Vitro Screening and MD Simulations of Thiourea Derivatives against SARS-CoV-2 in Association with Multidrug Resistance ABCB1 Transporter
por: Assad, Mohammad, et al.
Publicado: (2022)

Indole-3-acetamides: As Potential Antihyperglycemic and Antioxidant Agents; Synthesis, In Vitro α-Amylase Inhibitory Activity, Structure–Activity Relationship, and In Silico Studies
por: Kanwal,, et al.
Publicado: (2021)

Correction to “Indole-3-acetamides: As Potential Antihyperglycemic and Antioxidant Agents; Synthesis, In Vitro α-Amylase Inhibitory Activity, Structure–Activity Relationship, and In Silico Studies”
por: Kanwal,, et al.
Publicado: (2021)

Biosynthesis and Characterization of Silver Nanoparticles Using Tribulus terrestris Seeds: Revealed Promising Antidiabetic Potentials
por: Rahman, Abdur, et al.
Publicado: (2023)

Acute oral toxicity and antioxidant studies of an amine-based diselenide
por: Ibrahim, Mohammad, et al.
Publicado: (2019)

Accelerating Photocatalytic Hydrogen Production and Pollutant Degradation by Functionalizing g-C(3)N(4) With SnO(2)
por: Zada, Amir, et al.
Publicado: (2020)

Diagnostic and therapeutic delay in Rheumatoid Arthritis patients: Impact on disease outcome
por: Naeem, Faiza, et al.
Publicado: (2021)

Prevalence of Depressive Symptoms Among University Students in Pakistan: A Systematic Review and Meta-Analysis
por: Khan, Muhammad Naeem, et al.
Publicado: (2021)

The complete mitochondrial genome of blue pansy, Junonia orithya (Lepidoptera: Nymphalidae: Nymphalinae) from Pakistan
por: Bibi, Saira, et al.
Publicado: (2020)

Evaluation of the Hypoglycemic Activity of Morchella conica by Targeting Protein Tyrosine Phosphatase 1B
por: Begum, Naeema, et al.
Publicado: (2021)

Synthetic Transformation of 2-{2-Fluoro[1,1′-biphenyl]-4-yl} Propanoic Acid into Hydrazide–Hydrazone Derivatives: In Vitro Urease Inhibition and In Silico Study
por: Ahmad, Sajjad, et al.
Publicado: (2022)

Adherence to Methotrexate therapy in Rheumatoid Arthritis
por: Arshad, Nasim, et al.
Publicado: (2016)

Association of systemic lupus erythematosus disease activity index score with clinical and laboratory parameters in pediatric onset systemic lupus erythematosus
por: Shamim, Roshila, et al.
Publicado: (2020)

Evaluation of antioxidant, anti-inflammatory, analgesic and antipyretic activities of the stem bark of Sapindus mukorossi
por: Shah, Madeha, et al.
Publicado: (2017)

Cognitive dysfunction in patients with Systemic Lupus Erythematosus
por: Butt, Bilal Azeem, et al.
Publicado: (2017)

New azobenzene liquid crystal with dihydropyrazole heterocycle and photoisomerization studies
por: Wang, Xiaoxuan, et al.
Publicado: (2020)

Stress Driven Discovery of Natural Products From Actinobacteria with Anti-Oxidant and Cytotoxic Activities Including Docking and ADMET Properties
por: Hassan, Syed Shams ul, et al.
Publicado: (2021)

Substituted Benzimidazole Analogues as Potential α-Amylase Inhibitors and Radical Scavengers
por: Akande, Akinsola Adegboye, et al.
Publicado: (2021)

Depression in Rheumatoid Arthritis and its relation to disease activity
por: Imran, Muhammad Yaser, et al.
Publicado: (2015)

Facile synthesis of a CuSe/PVP nanocomposite for ultrasensitive non-enzymatic glucose biosensing
por: Rasheed, Momna, et al.
Publicado: (2023)

Co-Delivery of Curcumin and Cisplatin to Enhance Cytotoxicity of Cisplatin Using Lipid-Chitosan Hybrid Nanoparticles
por: Khan, Muhammad Muzamil, et al.
Publicado: (2020)

Microplastics in the Surface Water and Gastrointestinal Tract of Salmo trutta from the Mahodand Lake, Kalam Swat in Pakistan
por: Bilal, Muhammad, et al.
Publicado: (2022)

Parvimonas micra bacteremia in a patient with colonic carcinoma
por: Khan, Muhammad Shoaib, et al.
Publicado: (2019)

Antibacterial, Anticandidal, and Antibiofilm Potential of Fenchone: In Vitro, Molecular Docking and In Silico/ADMET Study
por: Ahmad, Wasim, et al.
Publicado: (2022)

Surgeon’s Experience May Circumvent Operative Volume in Improving Early Outcomes After Pancreaticoduodenectomy
por: Khan, Muhammad A, et al.
Publicado: (2023)

The Novelty of Icosapent Ethyl in the Management of Hypertriglyceridemia and Alleviating Cardiovascular Risk
por: Khan, Muhammad Shoaib, et al.
Publicado: (2021)

Assessment of potential drug–drug interactions and its associated factors in the hospitalized cardiac patients
por: Murtaza, Ghulam, et al.
Publicado: (2016)

New Hybrid Hydrazinyl Thiazole Substituted Chromones: As Potential α-Amylase Inhibitors and Radical (DPPH & ABTS) Scavengers
por: Salar, Uzma, et al.
Publicado: (2017)

4-Ethoxybenzohydrazide
por: Farman, Muhammad, et al.
Publicado: (2012)

Synthesis and Toxicity Evaluation of Some N(4)-Aryl Substituted 5-Trifluoromethoxyisatin-3-thiosemicarbazones
por: Pervez, Humayun, et al.
Publicado: (2011)

Metals-triggered compound CDPDP exhibits anti-arthritic behavior by downregulating the inflammatory cytokines, and modulating the oxidative storm in mice models with extensive ADMET, docking and simulation studies
por: Hassan, Syed Shams ul, et al.
Publicado: (2022)

Assessment of potential drug-related problems (PDRP) and clinical outcomes in bacterial meningitis patients admitted to tertiary care hospitals
por: Ali, Muhammad, et al.
Publicado: (2023)

Lung Nodule Detection in CT Images Using Statistical and Shape-Based Features
por: Khehrah, Noor, et al.
Publicado: (2020)

Nasal and perirectal colonization of vancomycin sensitive and resistant enterococci in patients of paediatrics ICU (PICU) of tertiary health care facilities
por: Yameen, Muhammad Arfat, et al.
Publicado: (2013)

Disease staging according to international scoring system in newly diagnosed patients with multiple myeloma
por: Shaikh, Saira Parveen, et al.
Publicado: (2019)

2-(2-Fluorobiphenyl-4-yl)-N′-(propan-2-ylidene)propanohydrazide
por: Khanum, Saira, et al.
Publicado: (2010)

1-(4-Ethoxybenzoyl)-4-(4-methoxyphenyl)thiosemicarbazide
por: Khanum, Saira, et al.
Publicado: (2009)

Cannot write session to /tmp/vufind_sessions/sess_vhmti0csheqs03nvu62cnm072j