Cargando…
Activity Models of Key GPCR Families in the Central Nervous System: A Tool for Many Purposes
[Image: see text] G protein-coupled receptors (GPCRs) are targets of many drugs, of which ∼25% are indicated for central nervous system (CNS) disorders. Drug promiscuity affects their efficacy and safety profiles. Predicting the polypharmacology profile of compounds against GPCRs can thus provide a...
| Autores principales: | , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical Society
2023
|
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10268961/ https://www.ncbi.nlm.nih.gov/pubmed/37257045 http://dx.doi.org/10.1021/acs.jcim.2c01531 |