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Activity Models of Key GPCR Families in the Central Nervous System: A Tool for Many Purposes

[Image: see text] G protein-coupled receptors (GPCRs) are targets of many drugs, of which ∼25% are indicated for central nervous system (CNS) disorders. Drug promiscuity affects their efficacy and safety profiles. Predicting the polypharmacology profile of compounds against GPCRs can thus provide a...

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Detalles Bibliográficos
Autores principales:	El-Atawneh, Shayma, Goldblum, Amiram
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2023
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10268961/ https://www.ncbi.nlm.nih.gov/pubmed/37257045 http://dx.doi.org/10.1021/acs.jcim.2c01531

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