Design of antibody variable fragments with reduced reactivity to preexisting anti-drug antibodies

Upon reformatting of an antibody to single-chain variable fragment format, a region in the former variable/constant domain interface of the heavy chain becomes accessible for preexisting (PE) anti-drug antibody (ADA) binding. The region exposed because of this reformatting contains a previously hidd...

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Detalles Bibliográficos
Autores principales: Johansson, Maria U., Weinert, Christopher, Reichardt, Dietrich Alexander, Mahler, Dana, Diem, Dania, Hess, Christian, Feusi, Diana, Carnal, Simon, Tietz, Julia, Giezendanner, Noreen, Spiga, Fabio Mario, Urech, David, Warmuth, Stefan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2023
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10269415/
https://www.ncbi.nlm.nih.gov/pubmed/37312434
http://dx.doi.org/10.1080/19420862.2023.2215887

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10269415/
https://www.ncbi.nlm.nih.gov/pubmed/37312434
http://dx.doi.org/10.1080/19420862.2023.2215887

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