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Design of antibody variable fragments with reduced reactivity to preexisting anti-drug antibodies
Upon reformatting of an antibody to single-chain variable fragment format, a region in the former variable/constant domain interface of the heavy chain becomes accessible for preexisting (PE) anti-drug antibody (ADA) binding. The region exposed because of this reformatting contains a previously hidd...
| Autores principales: | , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Taylor & Francis
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10269415/ https://www.ncbi.nlm.nih.gov/pubmed/37312434 http://dx.doi.org/10.1080/19420862.2023.2215887 |