A Refined, Controlled 16S rRNA Gene Sequencing Approach Reveals Limited Detection of Cerebrospinal Fluid Microbiota in Children with Bacterial Meningitis

Advances in both laboratory and computational components of high-throughput 16S amplicon sequencing (16S HTS) have markedly increased its sensitivity and specificity. Additionally, these refinements have better delineated the limits of sensitivity, and contributions of contamination to these limits,...

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Detalles Bibliográficos
Autores principales: Pope, Christopher E., Whitlock, Kathryn B., Hodor, Paul, Limbrick, David D., McDonald, Patrick J., Hauptman, Jason, Hoffman, Lucas R., Simon, Tamara D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10269467/
https://www.ncbi.nlm.nih.gov/pubmed/37140368
http://dx.doi.org/10.1128/spectrum.00361-23

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10269467/
https://www.ncbi.nlm.nih.gov/pubmed/37140368
http://dx.doi.org/10.1128/spectrum.00361-23

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