Cefiderocol Resistance in Klebsiella pneumoniae Is Linked to SHV Extended-Spectrum β-Lactamase Activities and Functional Loss of the Outer Membrane Porin OmpK35

Klebsiella pneumoniae AR 0047 from the CDC and FDA Antibiotic Resistance Isolate Bank is resistant to cefiderocol, a siderophore-conjugated cephalosporin. Genomics analysis and genetic complementation revealed that a frameshift mutation in ompK35 contributed to cefiderocol resistance. Heterologous e...

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Detalles Bibliográficos
Autores principales: Moon, Sun Hee, Huang, En
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10269512/
https://www.ncbi.nlm.nih.gov/pubmed/37097174
http://dx.doi.org/10.1128/spectrum.03496-22

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10269512/
https://www.ncbi.nlm.nih.gov/pubmed/37097174
http://dx.doi.org/10.1128/spectrum.03496-22

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