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SARS-CoV-2 Inhibits NRF2-Mediated Antioxidant Responses in Airway Epithelial Cells and in the Lung of a Murine Model of Infection

Several viruses have been shown to modulate the transcription factor nuclear factor erythroid 2-related factor 2 (NRF2), the master regulator of redox homeostasis. The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), responsible for the COVID-19 pandemic, also seems to disrupt the balan...

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Detalles Bibliográficos
Autores principales: Qu, Yue, Haas de Mello, Aline, Morris, Dorothea R., Jones-Hall, Yava L., Ivanciuc, Teodora, Sattler, Rachel A., Paessler, Slobodan, Menachery, Vineet D., Garofalo, Roberto P., Casola, Antonella
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10269779/
https://www.ncbi.nlm.nih.gov/pubmed/37022178
http://dx.doi.org/10.1128/spectrum.00378-23