New Perspectives on Escherichia coli Signal Peptidase I Substrate Specificity: Investigating Why the TasA Cleavage Site Is Incompatible with LepB Cleavage

Escherichia coli signal peptidase I (LepB) has been shown to inefficiently cleave secreted proteins with aromatic amino acids at the second position after the signal peptidase cleavage site (P2′). The Bacillus subtilis exported protein TasA contains a phenylalanine at P2′, which in B. subtilis is cl...

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Detalles Bibliográficos
Autores principales: Musik, Joanna E., Poole, Jessica, Day, Christopher J., Haselhorst, Thomas, Jen, Freda E.-C., Ve, Thomas, Masic, Veronika, Jennings, Michael P., Zalucki, Yaramah M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10269814/
https://www.ncbi.nlm.nih.gov/pubmed/37098897
http://dx.doi.org/10.1128/spectrum.05005-22

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10269814/
https://www.ncbi.nlm.nih.gov/pubmed/37098897
http://dx.doi.org/10.1128/spectrum.05005-22

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