Chemical Inhibition of Bromodomain Proteins in Insect-Stage African Trypanosomes Perturbs Silencing of the Variant Surface Glycoprotein Repertoire and Results in Widespread Changes in the Transcriptome

The eukaryotic protozoan parasite Trypanosoma brucei is transmitted by the tsetse fly to both humans and animals, where it causes a fatal disease called African trypanosomiasis. While the parasite lacks canonical DNA sequence-specific transcription factors, it does possess histones, histone modifica...

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Detalles Bibliográficos
Autores principales: Ashby, Ethan C., Havens, Jennifer L., Rollosson, Lindsey M., Hardin, Johanna, Schulz, Danae
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10269879/
https://www.ncbi.nlm.nih.gov/pubmed/37097159
http://dx.doi.org/10.1128/spectrum.00147-23

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10269879/
https://www.ncbi.nlm.nih.gov/pubmed/37097159
http://dx.doi.org/10.1128/spectrum.00147-23

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