Cargando…

LRRK2 and Parkinson's disease: from genetics to targeted therapy

LRRK2 variants are implicated in both familial and sporadic PD. LRRK2‐PD has a generally benign clinical presentation and variable pathology, with inconsistent presence of Lewy bodies and marked Alzheimer's disease pathology. The mechanisms underlying LRRK2‐PD are still unclear, but inflammatio...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sosero, Yuri L., Gan‐Or, Ziv
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2023
Materias:	Review Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10270275/ https://www.ncbi.nlm.nih.gov/pubmed/37021623 http://dx.doi.org/10.1002/acn3.51776

Ejemplares similares

Coding and Noncoding Variation in LRRK2 and Parkinson's Disease Risk
por: Lake, Julie, et al.
Publicado: (2021)

Targeting LRRK2 in Parkinson’s disease
por: Xiao, Bin, et al.
Publicado: (2022)

Precision medicine in Parkinson’s disease patients with LRRK2 and GBA risk variants – Let’s get even more personal
por: von Linstow, Christian U., et al.
Publicado: (2020)

LRRK2 and Proteostasis in Parkinson’s Disease
por: Pérez-Carrión, María Dolores, et al.
Publicado: (2022)

LRRK2 Targeting Strategies as Potential Treatment of Parkinson’s Disease
por: Wojewska, Dominika Natalia, et al.
Publicado: (2021)

LRRK2 and the Endolysosomal System in Parkinson’s Disease
por: Erb, Madalynn L., et al.
Publicado: (2020)

Genetic Variants of LRRK2 in Taiwanese Parkinson’s Disease
por: Wu, Yih-Ru, et al.
Publicado: (2013)

LRRK2 at the Crossroad of Aging and Parkinson’s Disease
por: Hur, Eun-Mi, et al.
Publicado: (2021)

Pathological Functions of LRRK2 in Parkinson’s Disease
por: Jeong, Ga Ram, et al.
Publicado: (2020)

Genetic and Environmental Factors Influence the Pleomorphy of LRRK2 Parkinsonism
por: Chittoor-Vinod, Vinita G., et al.
Publicado: (2021)

The role of the LRRK2 gene in Parkinsonism
por: Li, Jie-Qiong, et al.
Publicado: (2014)

LRRK2 and neuroinflammation: partners in crime in Parkinson’s disease?
por: Russo, Isabella, et al.
Publicado: (2014)

Roco Proteins and the Parkinson’s Disease-Associated LRRK2
por: Liao, Jingling, et al.
Publicado: (2018)

LRRK2 and Lipid Pathways: Implications for Parkinson’s Disease
por: Galper, Jasmin, et al.
Publicado: (2022)

Analysis of DNM3 and VAMP4 as genetic modifiers of LRRK2 Parkinson’s disease
por: Brown, Emmeline E., et al.
Publicado: (2021)

Models for LRRK2-Linked Parkinsonism
por: Li, Tianxia, et al.
Publicado: (2011)

Parkinson's disease and mitophagy: an emerging role for LRRK2
por: Singh, Francois, et al.
Publicado: (2021)

Genetic Analysis of LRRK2 R1628P in Parkinson's Disease in Asian Populations
por: Zhang, Yuan, et al.
Publicado: (2017)

LRRK2 and membrane trafficking: nexus of Parkinson’s disease
por: Hur, Eun-Mi, et al.
Publicado: (2019)

Overview of the Impact of Pathogenic LRRK2 Mutations in Parkinson’s Disease
por: Ito, Genta, et al.
Publicado: (2023)

Contribution of GTPase activity to LRRK2-associated Parkinson disease
por: Tsika, Elpida, et al.
Publicado: (2013)

The LRRK2–macroautophagy axis and its relevance to Parkinson's disease
por: Manzoni, Claudia
Publicado: (2017)

The Role of LRRK2 in Neurodegeneration of Parkinson Disease
por: Rui, Qin, et al.
Publicado: (2018)

LRRK2 as a Potential Genetic Modifier of Synucleinopathies: Interlacing the Two Major Genetic Factors of Parkinson's Disease
por: Hyun, Cheol Hwan, et al.
Publicado: (2013)

Modeling Parkinson’s disease in LRRK2 rodents
por: Domenicale, Chiara, et al.
Publicado: (2023)

Is Glial Dysfunction the Key Pathogenesis of LRRK2-Linked Parkinson’s Disease?
por: Iseki, Tatou, et al.
Publicado: (2023)

An Update on the Interplay between LRRK2, Rab GTPases and Parkinson’s Disease
por: Komori, Tadayuki, et al.
Publicado: (2023)

LRRK2 inhibitors and their potential in the treatment of Parkinson’s disease: current perspectives
por: Atashrazm, Farzaneh, et al.
Publicado: (2016)

LRRK2 in Parkinson's disease and dementia with Lewy bodies
por: Zhu, Xiongwei, et al.
Publicado: (2006)

From Synaptic Dysfunction to Neuroprotective Strategies in Genetic Parkinson’s Disease: Lessons From LRRK2
por: Mancini, Andrea, et al.
Publicado: (2020)

Mitochondrial DNA damage as a potential biomarker of LRRK2 kinase activity in LRRK2 Parkinson’s disease
por: Gonzalez-Hunt, C. P., et al.
Publicado: (2020)

What Have We Learned from Cerebrospinal Fluid Studies about Biomarkers for Detecting LRRK2 Parkinson’s Disease Patients and Healthy Subjects with Parkinson’s-Associated LRRK2 Mutations?
por: Loeffler, David A., et al.
Publicado: (2019)

A Link between Autophagy and the Pathophysiology of LRRK2 in Parkinson's Disease
por: Gómez-Suaga, Patricia, et al.
Publicado: (2012)

Activation Mechanism of LRRK2 and Its Cellular Functions in Parkinson's Disease
por: Rosenbusch, Katharina E., et al.
Publicado: (2016)

LRRK 2 gene mutations in the pathophysiology of the ROCO domain and therapeutic targets for Parkinson’s disease: a review
por: Chen, Meng-Ling, et al.
Publicado: (2018)

Is LRRK2 the missing link between inflammatory bowel disease and Parkinson’s disease?
por: Herrick, Mary K., et al.
Publicado: (2021)

LRRK2 contributes to monocyte dysregulation in Parkinson’s disease
por: Bliederhaeuser, Corinna, et al.
Publicado: (2016)

Metabolomic Profiling in LRRK2-Related Parkinson's Disease
por: Johansen, Krisztina K., et al.
Publicado: (2009)

miR-335 Targets LRRK2 and Mitigates Inflammation in Parkinson’s Disease
por: Oliveira, Sara R., et al.
Publicado: (2021)

LRRK2, GBA and their interaction in the regulation of autophagy: implications on therapeutics in Parkinson's disease
por: Pang, Shirley Yin-Yu, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_9f34gdl5bl2ej2691cc7hjojti