The generation of HepG2 transmitochondrial cybrids to reveal the role of mitochondrial genotype in idiosyncratic drug-induced liver injury

BACKGROUND: Evidence supports an important link between mitochondrial DNA (mtDNA) variation and adverse drug reactions such as idiosyncratic drug-induced liver injury (iDILI). Here, we describe the generation of HepG2-derived transmitochondrial cybrids, to investigate the impact of mtDNA variation o...

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Detalles Bibliográficos
Autores principales: Ball, Amy Louise, Jolly, Carol E, Lennon, Mark G, Lyon, Jonathan J, Alfirevic, Ana, Chadwick, Amy E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2023
Materias:
Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10270688/
https://www.ncbi.nlm.nih.gov/pubmed/37278519
http://dx.doi.org/10.7554/eLife.78187

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10270688/
https://www.ncbi.nlm.nih.gov/pubmed/37278519
http://dx.doi.org/10.7554/eLife.78187

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