Loss of cytochrome P450 (CYP)1B1 mitigates hyperoxia response in adult mouse lung by reprogramming metabolism and translation

Oxygen supplementation is life saving for premature infants and for COVID-19 patients but can induce long-term pulmonary injury by triggering inflammation, with xenobiotic-metabolizing CYP enzymes playing a critical role. Murine studies showed that CYP1B1 enhances, while CYP1A1 and CYP1A2 protect fr...

Descripción completa

Detalles Bibliográficos
Autores principales: Grimm, Sandra L., Stading, Rachel E., Robertson, Matthew J., Gandhi, Tanmay, Fu, Chenlian, Jiang, Weiwu, Xia, Guobin, Lingappan, Krithika, Coarfa, Cristian, Moorthy, Bhagavatula
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10271936/
https://www.ncbi.nlm.nih.gov/pubmed/37348155
http://dx.doi.org/10.1016/j.redox.2023.102790

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10271936/
https://www.ncbi.nlm.nih.gov/pubmed/37348155
http://dx.doi.org/10.1016/j.redox.2023.102790

Ejemplares similares