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Loss of cytochrome P450 (CYP)1B1 mitigates hyperoxia response in adult mouse lung by reprogramming metabolism and translation
Oxygen supplementation is life saving for premature infants and for COVID-19 patients but can induce long-term pulmonary injury by triggering inflammation, with xenobiotic-metabolizing CYP enzymes playing a critical role. Murine studies showed that CYP1B1 enhances, while CYP1A1 and CYP1A2 protect fr...
Autores principales: | Grimm, Sandra L., Stading, Rachel E., Robertson, Matthew J., Gandhi, Tanmay, Fu, Chenlian, Jiang, Weiwu, Xia, Guobin, Lingappan, Krithika, Coarfa, Cristian, Moorthy, Bhagavatula |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10271936/ https://www.ncbi.nlm.nih.gov/pubmed/37348155 http://dx.doi.org/10.1016/j.redox.2023.102790 |
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