Predicting the effect of different folate doses on [(68)Ga]Ga-PSMA-11 organ and tumor uptake using physiologically based pharmacokinetic modeling

BACKGROUND: Folate intake might reduce [(68)Ga]Ga-PSMA-11 uptake in tissues due to a competitive binding to the PSMA receptor. For diagnostic imaging, this could impact decision making, while during radioligand therapy this could affect treatment efficacy. The relationship between folate dose, timin...

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Detalles Bibliográficos
Autores principales: Siebinga, Hinke, Hendrikx, Jeroen J. M. A., Huitema, Alwin D. R., de Wit-van der Veen, Berlinda J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2023
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10272068/
https://www.ncbi.nlm.nih.gov/pubmed/37318681
http://dx.doi.org/10.1186/s13550-023-01008-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10272068/
https://www.ncbi.nlm.nih.gov/pubmed/37318681
http://dx.doi.org/10.1186/s13550-023-01008-y

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