Chemoproteomic target deconvolution reveals Histone Deacetylases as targets of (R)-lipoic acid

Lipoic acid is an essential enzyme cofactor in central metabolic pathways. Due to its claimed antioxidant properties, racemic (R/S)-lipoic acid is used as a food supplement but is also investigated as a pharmaceutical in over 180 clinical trials covering a broad range of diseases. Moreover, (R/S)-li...

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Detalles Bibliográficos
Autores principales: Lechner, Severin, Steimbach, Raphael R., Wang, Longlong, Deline, Marshall L., Chang, Yun-Chien, Fromme, Tobias, Klingenspor, Martin, Matthias, Patrick, Miller, Aubry K., Médard, Guillaume, Kuster, Bernhard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10272112/
https://www.ncbi.nlm.nih.gov/pubmed/37322067
http://dx.doi.org/10.1038/s41467-023-39151-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10272112/
https://www.ncbi.nlm.nih.gov/pubmed/37322067
http://dx.doi.org/10.1038/s41467-023-39151-8

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