N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics

Cysteine has been exploited as the binding site of covalent drugs. Its high sensitivity to oxidation is also important for regulating cellular processes. To identify new ligandable cysteines which can be hotspots for therapy and to better study cysteine oxidations, we develop cysteine-reactive probe...

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Detalles Bibliográficos
Autores principales: Koo, Tin-Yan, Lai, Hinyuk, Nomura, Daniel K., Chung, Clive Yik-Sham
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10272157/
https://www.ncbi.nlm.nih.gov/pubmed/37322008
http://dx.doi.org/10.1038/s41467-023-39268-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10272157/
https://www.ncbi.nlm.nih.gov/pubmed/37322008
http://dx.doi.org/10.1038/s41467-023-39268-w

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