Deregulation of mTORC1-TFEB axis in human iPSC model of GBA1-associated Parkinson’s disease

Mutations in the GBA1 gene are the single most frequent genetic risk factor for Parkinson’s disease (PD). Neurodegenerative changes in GBA1-associated PD have been linked to the defective lysosomal clearance of autophagic substrates and aggregate-prone proteins. To elucidate novel mechanisms contrib...

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Detalles Bibliográficos
Autores principales: Mubariz, Fahad, Saadin, Afsoon, Lingenfelter, Nicholas, Sarkar, Chinmoy, Banerjee, Aditi, Lipinski, Marta M., Awad, Ola
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10272450/
https://www.ncbi.nlm.nih.gov/pubmed/37332877
http://dx.doi.org/10.3389/fnins.2023.1152503

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10272450/
https://www.ncbi.nlm.nih.gov/pubmed/37332877
http://dx.doi.org/10.3389/fnins.2023.1152503

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