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IL-27-containing exosomes secreted by innate B-1a cells suppress and ameliorate uveitis

INTRODUCTION: IL-27 is a heterodimeric cytokine composed of Ebi3 and IL-27p28 and can exert proinflammatory or immune suppressive effects depending on the physiological context. Ebi3 does not contain membrane-anchoring motifs, suggesting that it is a secreted protein while IL-27p28 is poorly secrete...

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Detalles Bibliográficos
Autores principales:	Kang, Minkyung, Yadav, Manoj Kumar, Mbanefo, Evaristus C., Yu, Cheng-Rong, Egwuagu, Charles E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10272713/ https://www.ncbi.nlm.nih.gov/pubmed/37334383 http://dx.doi.org/10.3389/fimmu.2023.1071162

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