Exploration of T cell immune responses by expression of a dominant-negative SHP1 and SHP2

SHP1 and SHP2 are SH2 domain-containing proteins which have inhibitory phosphatase activity when recruited to phosphorylated ITIMs and ITSMs on inhibitory immune receptors. Consequently, SHP1 and SHP2 are key proteins in the transmission of inhibitory signals within T cells, constituting an importan...

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Detalles Bibliográficos
Autores principales: Taylor, Julia, Bulek, Anna, Gannon, Isaac, Robson, Mathew, Kokalaki, Evangelia, Grothier, Thomas, McKenzie, Callum, El-Kholy, Mohamed, Stavrou, Maria, Traynor-White, Charlotte, Lim, Wen Chean, Panagiotou, Panagiota, Srivastava, Saket, Baldan, Vania, Sillibourne, James, Ferrari, Mathieu, Pule, Martin, Thomas, Simon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10272835/
https://www.ncbi.nlm.nih.gov/pubmed/37334382
http://dx.doi.org/10.3389/fimmu.2023.1119350

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10272835/
https://www.ncbi.nlm.nih.gov/pubmed/37334382
http://dx.doi.org/10.3389/fimmu.2023.1119350

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