Cargando…

Lyn‐mediated glycolysis enhancement of microglia contributes to neuropathic pain through facilitating IRF5 nuclear translocation in spinal dorsal horn

The pro‐inflammatory phenotype of microglia usually induces neuroinflammatory reactions in neuropathic pain. Glycometabolism shift to glycolysis can promote the pro‐inflammatory phenotype transition of microglia. The omics data analysis suggest a critical role for Lyn dysregulation in neuropathic pa...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kong, Erliang, Li, Yongchang, Ma, Peng, Zhang, Yixuan, Ding, Ruifeng, Hua, Tong, Yang, Mei, Yuan, Hongbin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2023
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10273059/ https://www.ncbi.nlm.nih.gov/pubmed/37132040 http://dx.doi.org/10.1111/jcmm.17759

Ejemplares similares

Microglia and Inhibitory Circuitry in the Medullary Dorsal Horn: Laminar and Time-Dependent Changes in a Trigeminal Model of Neuropathic Pain
por: García-Magro, Nuria, et al.
Publicado: (2021)

Facilitation of neuropathic pain by the NPY Y1 receptor-expressing subpopulation of excitatory interneurons in the dorsal horn
por: Nelson, Tyler S., et al.
Publicado: (2019)

Immunofluorescence characterization of spinal cord dorsal horn microglia and astrocytes in horses
por: Meneses, Constanza Stefania, et al.
Publicado: (2017)

Yes and Lyn play a role in nuclear translocation of the Epidermal Growth Factor Receptor
por: Iida, Mari, et al.
Publicado: (2012)

Proteomic Analysis of the Spinal Dorsal Horn in Mice with Neuropathic Pain After Exercise
por: Bai, Jie, et al.
Publicado: (2023)

Endoplasmic reticulum stress impairment in the spinal dorsal horn of a neuropathic pain model
por: Zhang, Enji, et al.
Publicado: (2015)

Activation of locus coeruleus-spinal cord noradrenergic neurons alleviates neuropathic pain in mice via reducing neuroinflammation from astrocytes and microglia in spinal dorsal horn
por: Li, Juan, et al.
Publicado: (2022)

Glycinergic dysfunction in a subpopulation of dorsal horn interneurons in a rat model of neuropathic pain
por: Imlach, Wendy L., et al.
Publicado: (2016)

Effects of metformin on the expression of AMPK and STAT3 in the spinal dorsal horn of rats with neuropathic pain
por: Ge, Anqi, et al.
Publicado: (2018)

Mitochondrial superoxide increases excitatory synaptic strength in spinal dorsal horn neurons of neuropathic mice
por: Bae, Chilman, et al.
Publicado: (2018)

Functional Reorganization of Local Circuit Connectivity in Superficial Spinal Dorsal Horn with Neuropathic Pain States
por: Gong, Nian, et al.
Publicado: (2019)

Hypoxia-induced carbonic anhydrase mediated dorsal horn neuron activation and induction of neuropathic pain
por: Da Vitoria Lobo, Marlene E., et al.
Publicado: (2022)

Crosstalk between Activated Microglia and Neurons in the Spinal Dorsal Horn Contributes to Stress-induced Hyperalgesia
por: Qi, Jian, et al.
Publicado: (2016)

Glycometabolism Reprogramming of Glial Cells in Central Nervous System: Novel Target for Neuropathic Pain
por: Kong, Erliang, et al.
Publicado: (2022)

Downregulation of nuclear STAT2 protein in the spinal dorsal horn is involved in neuropathic pain following chronic constriction injury of the rat sciatic nerve
por: Huang, Zhifeng, et al.
Publicado: (2023)

Inhibition of NKCC1 in spinal dorsal horn and dorsal root ganglion results in alleviation of neuropathic pain in rats with spinal cord contusion
por: Wu, Yao, et al.
Publicado: (2023)

Electroacupuncture Alleviates Diabetic Neuropathic Pain and Downregulates p-PKC and TRPV1 in Dorsal Root Ganglions and Spinal Cord Dorsal Horn
por: Ma, Yi-qi, et al.
Publicado: (2023)

Dorsal horn neurons release extracellular ATP in a VNUT-dependent manner that underlies neuropathic pain
por: Masuda, Takahiro, et al.
Publicado: (2016)

Systemic Injection of Thalidomide Prevent and Attenuate Neuropathic Pain and Alleviate Neuroinflammatory Response in the Spinal Dorsal Horn
por: Xu, Hao, et al.
Publicado: (2019)

Z-Guggulsterone Relieves Neuropathic Pain by Inhibiting the Expression of Astrocytes and Proinflammatory Cytokines in the Spinal Dorsal Horn
por: Dang, Sha-Jie, et al.
Publicado: (2022)

Activation of the bile acid receptors TGR5 and FXR in the spinal dorsal horn alleviates neuropathic pain
por: Wu, Yuning, et al.
Publicado: (2023)

Is BDNF sufficient for information transfer between microglia and dorsal horn neurons during the onset of central sensitization?
por: Biggs, James E, et al.
Publicado: (2010)

Phenylmethimazole Blocks dsRNA-Induced IRF3 Nuclear Translocation and Homodimerization
por: Courreges, Maria C., et al.
Publicado: (2012)

Gene Therapy for Neuropathic Pain through siRNA-IRF5 Gene Delivery with Homing Peptides to Microglia
por: Terashima, Tomoya, et al.
Publicado: (2018)

Chemokine CCL2 and its receptor CCR2 in the medullary dorsal horn are involved in trigeminal neuropathic pain
por: Zhang, Zhi-Jun, et al.
Publicado: (2012)

Tet1-dependent epigenetic modification of BDNF expression in dorsal horn neurons mediates neuropathic pain in rats
por: Hsieh, Ming-Chun, et al.
Publicado: (2016)

Targeted up-regulation of Drp1 in dorsal horn attenuates neuropathic pain hypersensitivity by increasing mitochondrial fission
por: Zhang, Kun-Long, et al.
Publicado: (2021)

Interferon-γ facilitates the synaptic transmission between primary afferent C-fibres and lamina I neurons in the rat spinal dorsal horn via microglia activation
por: Reischer, Gerda, et al.
Publicado: (2020)

Defining populations of dorsal horn interneurons
por: Graham, Brett A., et al.
Publicado: (2020)

Interferon-gamma potentiates NMDA receptor signaling in spinal dorsal horn neurons via microglia–neuron interaction
por: Sonekatsu, Mayumi, et al.
Publicado: (2016)

Transcription factor IRF5 drives P2X4R(+)-reactive microglia gating neuropathic pain
por: Masuda, Takahiro, et al.
Publicado: (2014)

Screening and Identification of Key Genes, Pathways, and Drugs Associated with Neuropathic Pain in Dorsal Horn: Evidence from Bioinformatic Analysis
por: Yang, Xiao, et al.
Publicado: (2021)

IRF3 prevents colorectal tumorigenesis via inhibiting the nuclear translocation of β-catenin
por: Tian, Miao, et al.
Publicado: (2020)

IRF3 inhibits nuclear translocation of NF-κB to prevent viral inflammation
por: Popli, Sonam, et al.
Publicado: (2022)

A phospho-tyrosine–based signaling module using SPOP, CSK, and LYN controls TLR-induced IRF activity
por: Tawaratsumida, Kazuki, et al.
Publicado: (2022)

The Cellular and Synaptic Architecture of the Mechanosensory Dorsal Horn
por: Abraira, Victoria E., et al.
Publicado: (2017)

Transient receptor potential ankyrin 1 in spinal cord dorsal horn is involved in neuropathic pain in nerve root constriction rats
por: Miyakawa, Tsuyoshi, et al.
Publicado: (2014)

Effects of 1,8-cineole on neuropathic pain mediated by P2X2 receptor in the spinal cord dorsal horn
por: Zheng, Xiao-bo, et al.
Publicado: (2019)

Long Non-coding RNA and mRNA Expression Change in Spinal Dorsal Horn After Exercise in Neuropathic Pain Rats
por: Song, Ge, et al.
Publicado: (2022)

Dexmedetomidine alleviated neuropathic pain in dorsal root ganglion neurons by inhibition of anaerobic glycolysis activity and enhancement of ROS tolerance
por: Liu, Peibin, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_t54o4q2vbjlgvjevkc45ujvq4u