Enzyme-Responsive Zr-Based Metal–Organic Frameworks for Controlled Drug Delivery: Taking Advantage of Clickable PEG-Phosphate Ligands

[Image: see text] We report for the first time the controlled drug release from a nanoscale Zr-based metal–organic framework (MOF), UiO-66, in the presence of the enzyme alkaline phosphatase (ALP). This unprecedented reactivity was possible thanks to the prior functionalization of the MOF with N(3)–...

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Detalles Bibliográficos
Autores principales: Carrillo-Carrión, Carolina, Comaills, Valentine, Visiga, Ana M., Gauthier, Benoit R., Khiar, Noureddine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10273175/
https://www.ncbi.nlm.nih.gov/pubmed/37249914
http://dx.doi.org/10.1021/acsami.3c03230

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10273175/
https://www.ncbi.nlm.nih.gov/pubmed/37249914
http://dx.doi.org/10.1021/acsami.3c03230

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