Cargando…

Ion Mobility Mass Spectrometry Unveils Global Protein Conformations in Response to Conditions that Promote and Reverse Liquid–Liquid Phase Separation

[Image: see text] Liquid–liquid phase separation (LLPS) is a process by which biomacromolecules, particularly proteins, condense into a dense phase that resembles liquid droplets. Dysregulation of LLPS is implicated in disease, yet the relationship between protein conformational changes and LLPS rem...

Descripción completa

Detalles Bibliográficos
Autores principales:	Robb, Christina Glen, Dao, Thuy P., Ujma, Jakub, Castañeda, Carlos A., Beveridge, Rebecca
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2023
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10273310/ https://www.ncbi.nlm.nih.gov/pubmed/37276246 http://dx.doi.org/10.1021/jacs.3c00756

Ejemplares similares

Characterization of Biodegraded Ignitable Liquids by Headspace–Ion Mobility Spectrometry
por: P. Calle, José Luis, et al.
Publicado: (2020)

Gas Phase Stability of Protein Ions in a Cyclic Ion Mobility Spectrometry Traveling Wave Device
por: Eldrid, Charles, et al.
Publicado: (2019)

Liquid-liquid phase separation induces pathogenic tau conformations in vitro
por: Kanaan, Nicholas M., et al.
Publicado: (2020)

Liquid chromatography and differential mobility spectrometry—data-independent mass spectrometry for comprehensive multidimensional separations in metabolomics
por: Ekmekciu, Lysi, et al.
Publicado: (2023)

Cyclic Ion Mobility Mass Spectrometry Distinguishes Anomers and Open-Ring Forms of Pentasaccharides
por: Ujma, Jakub, et al.
Publicado: (2019)

LESA Cyclic Ion Mobility Mass Spectrometry of Intact Proteins from Thin Tissue Sections
por: Sisley, Emma K., et al.
Publicado: (2020)

Role of protein conformation and weak interactions on γ-gliadin liquid-liquid phase separation
por: Sahli, Line, et al.
Publicado: (2019)

Protein Unfolding in Freeze Frames: Intermediate States are Revealed by Variable-Temperature Ion Mobility–Mass Spectrometry
por: Ujma, Jakub, et al.
Publicado: (2022)

Preconcentration and Determination of Psychotropic Drugs in Urine Samples by Ion Mobility Spectrometry with Electrospray Ionization Coupling On-Line Single-Drop Liquid-Liquid-Liquid Microextraction
por: Li, Shu
Publicado: (2019)

Unwrapping Wrap-around in Gas (or Liquid) Chromatographic Cyclic Ion Mobility–Mass Spectrometry
por: Breen, Jake, et al.
Publicado: (2022)

Liquid–liquid phase separation of full-length prion protein initiates conformational conversion in vitro
por: Tange, Hiroya, et al.
Publicado: (2021)

Direct Observation of “Elongated” Conformational States in α‐Synuclein upon Liquid‐Liquid Phase Separation
por: Ubbiali, Daniele, et al.
Publicado: (2022)

Multiple Enzymatic Digestions and Ion Mobility Separation Improve Quantification of Bacterial Ribosomal Proteins by Data Independent Acquisition Liquid Chromatography−Mass Spectrometry
por: Dator, Romel P., et al.
Publicado: (2014)

Ion Mobility Mass Spectrometry Uncovers the Impact of the Patterning of Oppositely Charged Residues on the Conformational Distributions of Intrinsically Disordered Proteins
por: Beveridge, Rebecca, et al.
Publicado: (2019)

Ion mobility spectrometry combined with ultra performance liquid chromatography/mass spectrometry for metabolic phenotyping of urine: Effects of column length, gradient duration and ion mobility spectrometry on metabolite detection
por: Rainville, Paul D., et al.
Publicado: (2017)

Characterization of the Exometabolome of Nitrosopumilus maritimus SCM1 by Liquid Chromatography–Ion Mobility Mass Spectrometry
por: Law, Kai P., et al.
Publicado: (2021)

Pathologic tau conformer ensembles induce dynamic, liquid-liquid phase separation events at the nuclear envelope
por: Kang, Sang-Gyun, et al.
Publicado: (2021)

Utilizing liquid chromatography, ion mobility spectrometry, and mass spectrometry to assess INLIGHT™ derivatized N-linked glycans in biological samples
por: Butler, Karen E., et al.
Publicado: (2021)

Dextran as internal calibrant for N-glycan analysis by liquid chromatography coupled to ion mobility-mass spectrometry
por: Manz, Christian, et al.
Publicado: (2022)

Comprehensive Steroid Assay with Non-Targeted Analysis Using Liquid Chromatography Ion Mobility Mass Spectrometry
por: Yamakawa, Mai, et al.
Publicado: (2022)

Liquid–liquid phase separation in autophagy
por: Noda, Nobuo N., et al.
Publicado: (2020)

RNA and liquid-liquid phase separation
por: Guo, Qi, et al.
Publicado: (2021)

Thermodynamic Insights into the Separation of Carotenoids in Reversed-Phase Liquid Chromatography
por: Marchetti, Nicola, et al.
Publicado: (2019)

A Conserved Core Region of the Scaffold NEMO is Essential for Signal-induced Conformational Change and Liquid-liquid Phase Separation
por: DiRusso, Christopher J., et al.
Publicado: (2023)

A conserved core region of the scaffold NEMO is essential for signal-induced conformational change and liquid-liquid phase separation
por: DiRusso, Christopher J., et al.
Publicado: (2023)

Untargeted lipidomics using liquid chromatography-ion mobility-mass spectrometry reveals novel triacylglycerides in human milk
por: George, Alexandra D., et al.
Publicado: (2020)

Integrating the potential of ion mobility spectrometry-mass spectrometry in the separation and structural characterisation of lipid isomers
por: Camunas-Alberca, Sandra M., et al.
Publicado: (2023)

Liquid–Liquid Phase Separation in Crowded Environments
por: André, Alain A. M., et al.
Publicado: (2020)

Targeting viral liquid–liquid phase separation
por: York, Ashley
Publicado: (2021)

Liquid–liquid phase separation in tumor biology
por: Tong, Xuhui, et al.
Publicado: (2022)

Review on Liquid–Liquid Separation by Membrane Filtration
por: Divakar, Swathi, et al.
Publicado: (2022)

Open questions on liquid–liquid phase separation
por: Spruijt, Evan
Publicado: (2023)

Liquid–Liquid Phase Separation in Cardiovascular Diseases
por: Mo, Yuanxi, et al.
Publicado: (2022)

Biomolecular Liquid–Liquid Phase Separation for Biotechnology
por: Shil, Sumit, et al.
Publicado: (2023)

Combined hydrophilic interaction liquid chromatography-scanning field asymmetric waveform ion mobility spectrometry-time-of-flight mass spectrometry for untargeted metabolomics
por: Szykuła, Katarzyna M., et al.
Publicado: (2019)

A Strategy for Identification and Structural Characterization of Compounds from Plantago asiatica L. by Liquid Chromatography-Mass Spectrometry Combined with Ion Mobility Spectrometry
por: Gao, Hongxue, et al.
Publicado: (2022)

A Systematical Analysis of Tryptic Peptide Identification with Reverse Phase Liquid Chromatography and Electrospray Ion Trap Mass Spectrometry
por: Sun, Wei, et al.
Publicado: (2004)

Mass Spectrometry of RNA-Binding Proteins during Liquid–Liquid Phase Separation Reveals Distinct Assembly Mechanisms and Droplet Architectures
por: Sahin, Cagla, et al.
Publicado: (2023)

Contribution of Capillary Zone Electrophoresis Hyphenated with Drift Tube Ion Mobility Mass Spectrometry as a Complementary Tool to Microfluidic Reversed Phase Liquid Chromatography for Antigen Discovery
por: Gou, Marie-Jia, et al.
Publicado: (2022)

The critical role of mobile phase pH in the performance of oligonucleotide ion-pair liquid chromatography–mass spectrometry methods
por: Guimaraes, Guilherme J, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_3sev8fpv8t9v8v9cumu2npkttk