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Exploring the inhibition of the soluble lytic transglycosylase Cj0843c of Campylobacter jejuni via targeting different sites with different scaffolds
Bacterial lytic transglycosylases (LTs) contribute to peptidoglycan cell wall metabolism and are potential drug targets to potentiate β‐lactam antibiotics to overcome antibiotic resistance. Since LT inhibitor development is underexplored, we probed 15 N‐acetyl‐containing heterocycles in a structure‐...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley & Sons, Inc.
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10273340/ https://www.ncbi.nlm.nih.gov/pubmed/37209283 http://dx.doi.org/10.1002/pro.4683 |