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Exploring the inhibition of the soluble lytic transglycosylase Cj0843c of Campylobacter jejuni via targeting different sites with different scaffolds

Bacterial lytic transglycosylases (LTs) contribute to peptidoglycan cell wall metabolism and are potential drug targets to potentiate β‐lactam antibiotics to overcome antibiotic resistance. Since LT inhibitor development is underexplored, we probed 15 N‐acetyl‐containing heterocycles in a structure‐...

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Detalles Bibliográficos
Autores principales:	Kumar, Vijay, Boorman, Jacob, Greenlee, William J., Zeng, Ximin, Lin, Jun, van den Akker, Focco
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley & Sons, Inc. 2023
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10273340/ https://www.ncbi.nlm.nih.gov/pubmed/37209283 http://dx.doi.org/10.1002/pro.4683

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