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Big versus small: The impact of aggregate size in disease

Protein aggregation results in an array of different size soluble oligomers and larger insoluble fibrils. Insoluble fibrils were originally thought to cause neuronal cell deaths in neurodegenerative diseases due to their prevalence in tissue samples and disease models. Despite recent studies demonst...

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Detalles Bibliográficos
Autores principales: Hnath, Brianna, Chen, Jiaxing, Reynolds, Joshua, Choi, Esther, Wang, Jian, Zhang, Dongyan, Sha, Congzhou M., Dokholyan, Nikolay V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10273386/
https://www.ncbi.nlm.nih.gov/pubmed/37243896
http://dx.doi.org/10.1002/pro.4686