Liver-specific in vivo base editing of Angptl3 via AAV delivery efficiently lowers blood lipid levels in mice

BACKGROUND: Gene editing has emerged as an exciting therapeutic development platform for numerous genetic and nongenetic diseases. Targeting lipid-modulating genes such as angiopoietin-related protein 3 (ANGPTL3) with gene editing offers hope for a permanent solution to lower cardiovascular disease...

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Detalles Bibliográficos
Autores principales: Zuo, Yuanbojiao, Zhang, Chen, Zhou, Yuan, Li, Haiwen, Xiao, Weidong, Herzog, Roland W., Xu, Jie, Zhang, Jifeng, Chen, Y. Eugene, Han, Renzhi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10273718/
https://www.ncbi.nlm.nih.gov/pubmed/37322547
http://dx.doi.org/10.1186/s13578-023-01036-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10273718/
https://www.ncbi.nlm.nih.gov/pubmed/37322547
http://dx.doi.org/10.1186/s13578-023-01036-0

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