Mitochondrial DNA induces nucleus pulposus cell pyroptosis via the TLR9-NF-κB-NLRP3 axis

BACKGROUND: Nucleus pulposus cell (NPC) death and progressive reduction play important roles in intervertebral disc degeneration (IVDD). As part of a damage-associated molecular pattern, mitochondrial DNA (mtDNA) can be recognized by TLR9 and triggers the expression of NF-κB and NLRP3 inflammasomes,...

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Detalles Bibliográficos
Autores principales: Lu, Peng, Zheng, Huayong, Meng, Hao, Liu, Chuan, Duan, Lianhong, Zhang, Jianzheng, Zhang, Zhicheng, Gao, Jie, Zhang, Yang, Sun, Tiansheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10273761/
https://www.ncbi.nlm.nih.gov/pubmed/37322517
http://dx.doi.org/10.1186/s12967-023-04266-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10273761/
https://www.ncbi.nlm.nih.gov/pubmed/37322517
http://dx.doi.org/10.1186/s12967-023-04266-5

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