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Mitochondrial DNA induces nucleus pulposus cell pyroptosis via the TLR9-NF-κB-NLRP3 axis

BACKGROUND: Nucleus pulposus cell (NPC) death and progressive reduction play important roles in intervertebral disc degeneration (IVDD). As part of a damage-associated molecular pattern, mitochondrial DNA (mtDNA) can be recognized by TLR9 and triggers the expression of NF-κB and NLRP3 inflammasomes,...

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Detalles Bibliográficos
Autores principales:	Lu, Peng, Zheng, Huayong, Meng, Hao, Liu, Chuan, Duan, Lianhong, Zhang, Jianzheng, Zhang, Zhicheng, Gao, Jie, Zhang, Yang, Sun, Tiansheng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10273761/ https://www.ncbi.nlm.nih.gov/pubmed/37322517 http://dx.doi.org/10.1186/s12967-023-04266-5

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