ENPP1 is an innate immune checkpoint of the anticancer cGAMP-STING pathway

ENPP1 expression correlates with poor prognosis in many cancers, and we previously discovered that ENPP1 is the dominant hydrolase of extracellular cGAMP: a cancer-cell-produced immunotransmitter that activates the anticancer STING pathway. However, ENPP1 has other catalytic activities and the molec...

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Detalles Bibliográficos
Autores principales: Wang, Songnan, Böhnert, Volker, Joseph, Alby J., Sudaryo, Valentino, Swinderman, Jason, Yu, Feiqiao B., Lyu, Xuchao, Skariah, Gemini, Subramanyam, Vishvak, Gilbert, Luke A., Goodarzi, Hani, Lingyin, Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10274658/
https://www.ncbi.nlm.nih.gov/pubmed/37333273
http://dx.doi.org/10.1101/2023.06.01.543353

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10274658/
https://www.ncbi.nlm.nih.gov/pubmed/37333273
http://dx.doi.org/10.1101/2023.06.01.543353

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