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α-synuclein promotes neuronal dysfunction and death by disrupting the binding of ankyrin to ß-spectrin
α-synuclein plays a key role in the pathogenesis of Parkinson’s disease and related disorders, but critical interacting partners and molecular mechanisms mediating neurotoxicity are incompletely understood. We show that α-synuclein binds directly to ß-spectrin. Using males and females in a Drosophil...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Cold Spring Harbor Laboratory
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10274672/ https://www.ncbi.nlm.nih.gov/pubmed/37333277 http://dx.doi.org/10.1101/2023.06.02.543481 |